Tributyltin-mediated hepatic, renal and testicular tissue damage in male Syrian hamster (Mesocricetus auratus): a study on impact of oxidative stress
نویسندگان
چکیده
Organotin compounds are a versatile group of organometallic chemicals that are used in a variety of industrial and agricultural applications. Tributyltin (TBT), a common organotin, brings about severe spermatotoxic and organotoxic effects. However, information about the adverse effects of TBT on liver, kidney and testis is scanty. Hence, the present study was undertaken to elucidate the TBT-mediated oxidative stress-induced impairments in these organs. Administration of TBT through oral route at increasing doses of 50, 100 and 150 ppm for 65 days to male Syrian hamsters resulted in drastically decreased activities of antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase and decreased mean levels of non-enzymatic antioxidants (reduced glutathione, vitamin C, and vitamin E) followed by a dramatic increase in the levels of lipid peroxidation in the liver, kidney and testis as compared to the control animals. Significantly high levels of serum urea, creatinine, uric acid and bilirubin were observed in TBT-treated hamsters. Also, TBT treatment induced drastic histopathological changes in the liver, kidney and testis combined with remarkable changes in serum levels of tissue injury marker enzymes Aspartate transaminases, Alkaline phosphatase and Alanine transaminase. These data affirm that exposure to TBT can lead to oxidative stress-induced damage to liver, kidney and testis.
منابع مشابه
The effect of coenzyme Q10 on oxidative stress parameters and testicular tissue damage in rats following monosodium glutamate induced excitatory intoxication
Background: Monosodium glutamate (MSG) is known as a food flavor enhancer that can adversely affect the male reproductive system. The present study was investigated the protective effect of coenzyme Q10 (Co-Q10) against MSG-induced oxidative stress and histopathological changes in rat testicular tissue. Materials and methods: In this experimental study, 40 adult male Wistar rats were randomly ...
متن کاملModulatory Effect of Pioglitazone on Sperm Parameters and Oxidative Stress, Apoptotic and Inflammatory Biomarkers in Testes of Streptozotocin-Induced Diabetic Rats
Background and Aims: Diabetes mellitus causes testicular damage by increasing oxidative stress and inflammation. In the present study, modulation of oxidative stress by pioglitazone, a synthetic ligand of peroxisome proliferator-activated receptor-γ, was examined in testis of streptozotocin-induced diabetic rats. Materials and Methods: Diabetes was induced by a single dose of streptozot...
متن کاملCurcumin Ameliorates Sertraline-mediated Testicular Toxicity in Rats via Inhibition of Oxidative Stress
Background: Sertraline is prescribed mainly for the treatment of patients with depression. However, this drug is known to have toxic effects on the male germ cells. Therefore, this study was designed to examine the ameliorative effects of curcumin on the sertraline-induced male reproductive toxicity. Methods: Thirty-two male Wistar rats were randomly divided into four groups of eight each. The...
متن کاملEffects of chronic ethanol consumption on male Syrian hamster hepatic, microsomal mixed-function oxidases.
Chronic alcohol consumption significantly increases the risk of drug interactions. We have described its effects on hamster microsomal monooxygenases. Male Syrian hamsters (85 g) were given 10% ethanol in water and food ad lib for up to 6 weeks. Microsomal electron transport components and metabolism of ethylmorphine, benzphetamine, aniline, and acetaminophen were measured. At 4 weeks, SDS-PAGE...
متن کامل